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Symbol
Name
ID

Zeb2
zinc finger E-box binding homeobox 2
MGI:1344407

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Drooling

Abnormal enteric ganglion morphology

Aganglionic megacolon

Dysphagia

Spasticity

Morphological central nervous system abnormality

Ventriculomegaly

Polymicrogyria

Focal cortical dysplasia

Large basal ganglia

Abnormal cerebral white matter morphology

Abnormal corpus callosum morphology

Agenesis of corpus callosum

Hypoplasia of the corpus callosum

Aplasia/Hypoplasia of the cerebral white matter

Focal white matter lesions

Abnormal hippocampus morphology

Agenesis of cerebellar vermis

Cerebellar vermis hypoplasia

Enlarged cerebellum

Periventricular heterotopia

Ataxia

EEG with generalized slow activity

EEG with spike-wave complexes

Absent speech

Expressive aphasia

Delayed speech and language development

Anxiety

Happy demeanor

Reduced social reciprocity

Motor stereotypy

Bruxism

Intellectual disability

Intellectual disability, moderate

Intellectual disability, severe

Sleep abnormality

Broad-based gait

Inability to walk

Developmental regression

Neurodevelopmental delay

Motor delay

Delayed fine motor development

Delayed ability to walk

Seizure

Atypical absence seizure

Focal-onset seizure

Status epilepticus

Impaired pain sensation

Disease(s) Associated with ZEB2

Hirschsprung's disease

Mowat-Wilson syndrome

Mouse Phenotypes		nervous system phenotype	abnormal neural plate morphology	abnormal melanoblast morphology	absent vagal neural crest cells	open neural tube
Availability	Mouse Genotype	nervous system phenotype	abnormal neural plate morphology	abnormal melanoblast morphology	absent vagal neural crest cells	open neural tube
	Zeb2^tm1.2Yhi/Zeb2^tm1.2Yhi
	Zeb2^tm1.2Yhi/Zeb2⁺	*
	Zeb2^tm1.1Yhi/Zeb2^tm1.1Yhi Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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